Numerically Computing QCD Laplace Sum-Rules Using pySecDec

pySecDec is a program that numerically calculates dimensionally regularized integrals. We use pySecDec to compute QCD Laplace sum-rules for pseudoscalar (i.e., $J^{PC}=0^{-+}$) charmonium hybrids, and compare the results to sum-rules computed using analytic results for dimensionally regularized integrals. We find that the errors due to the use of numerical integration methods is negligible compared to the uncertainties in the sum-rules stemming from the uncertainties in the parameters of QCD, e.g., the coupling constant, quark masses, and condensate values. Also, we demonstrate that numerical integration methods can be used to calculate finite-energy and Gaussian sum-rules in addition to Laplace sum-rules.Comment: 10 pages, 5 figure

Drug-like analogues of the parasitic worm-derived immunomodulator ES-62 are therapeutic in the MRL/Lpr model of systemic lupus erythematosus

Introduction ES-62, a phosphorylcholine (PC)-containing immunomodulator secreted by the parasitic worm Acanthocheilonema viteae, protects against nephritis in the MRL/Lpr mouse model of systemic lupus erythematosus (SLE). However, ES-62 is not suitable for development as a therapy and thus we have designed drug-like small molecule analogues (SMAs) based around its active PC-moiety. To provide proof of concept that ES-62-based SMAs exhibit therapeutic potential in SLE, we have investigated the capacity of two SMAs to protect against nephritis when administered to MRL/Lpr mice after onset of kidney damage. Methods SMAs 11a and 12b were evaluated for their ability to suppress antinuclear antibody (ANA) generation and consequent kidney pathology in MRL/Lpr mice when administered after the onset of proteinuria. Results SMAs 11a and 12b suppressed development of ANA and proteinuria. Protection reflected downregulation of MyD88 expression by kidney cells and this was associated with reduced production of IL-6, a cytokine that exhibits promise as a therapeutic target for this condition. Conclusions SMAs 11a and 12b provide proof of principle that synthetic compounds based on the safe immunomodulatory mechanisms of parasitic worms can exhibit therapeutic potential as a novel class of drugs for SLE, a disease for which current therapies remain inadequate

Masses of Open-Flavour Heavy-Light Hybrids from QCD Sum-Rules

We use QCD Laplace sum-rules to predict masses of open-flavour heavy-light hybrids where one of the hybrid's constituent quarks is a charm or bottom and the other is an up, down, or strange. We compute leading-order, diagonal correlation functions of several hybrid interpolating currents, taking into account QCD condensates up to dimension-six, and extract hybrid mass predictions for all $J^P\in\{0^{\pm},\,1^{\pm}\}$, as well as explore possible mixing effects with conventional quark-antiquark mesons. Within theoretical uncertainties, our results are consistent with a degeneracy between the heavy-nonstrange and heavy-strange hybrids in all $J^P$ channels. We find a similar mass hierarchy of $1^+$, $1^{-}$, and $0^+$ states (a $1^{+}$ state lighter than essentially degenerate $1^{-}$ and $0^{+}$ states) in both the charm and bottom sectors, and discuss an interpretation for the $0^-$ states. If conventional meson mixing is present the effect is an increase in the hybrid mass prediction, and we estimate an upper bound on this effect.Comment: 24 pages, 8 figures. Mass predictions updated from previous version to reflect corrected sign error in sum rule analysis. Mixing analysis and examination of higher weight sum-rules added. To be published in JHE

Gaussian Sum-Rule Analysis of Scalar Gluonium and Quark Mesons

Gaussian sum-rules, which are related to a two-parameter Gaussian-weighted integral of a hadronic spectral function, are able to examine the possibility that more than one resonance makes a significant contribution to the spectral function. The Gaussian sum-rules, including instanton effects, for scalar gluonic and non-strange scalar quark currents clearly indicate a distribution of the resonance strength in their respective spectral functions. Furthermore, analysis of a two narrow resonance model leads to excellent agreement between theory and phenomenology in both channels. The scalar quark and gluonic sum-rules are remarkably consistent in their prediction of masses of approximately 1.0 GeV and 1.4 GeV within this model. Such a similarity would be expected from hadronic states which are mixtures of gluonium and quark mesons.Comment: latex2e using amsmath, 11 pages, 4 eps figures embedded in latex file. Write-up of presentation for the 2003 SUNY IT (Utica) workshop on scalar meson